Locally Advanced Prostate Cancer
Locally Advanced Prostate Cancer: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.
Disclaimer:
This blog is for informational purposes only and should not be taken as medical advice. Content is sourced from third parties, and we do not guarantee accuracy or accept any liability for its use. Always consult a qualified healthcare professional for medical guidance.
What is Locally Advanced Prostate Cancer?
Locally advanced prostate cancer (stage III) has spread beyond the prostate to nearby tissues/seminal vesicles/lymph nodes, but not distant. It’s adenocarcinoma, with Gleason 8-10 often. In 2025, part of ~313,780 diagnoses, treatable but with recurrence risk.
Symptoms
Symptoms include urinary obstruction, frequent urination, blood in urine/semen, erectile dysfunction, pelvic pain, bone pain if spread. Many asymptomatic. In 2025, PSA screening detects.
Causes
Causes mirror localised: age, family history, African ancestry, mutations (BRCA). Progression from localised due to delayed treatment. In 2025, androgen resistance is key.
Diagnosis
Diagnosis uses PSA, DRE, biopsy (Gleason), MRI for extent, bone scan/PET for nodes. Staging TNM. In 2025, PSMA PET improves accuracy.
Treatment
Treatment includes radiation + ADT, radical prostatectomy + radiation, chemo for high-risk. In 2025, combinations like ADT + abiraterone extend PFS.
Future Outlook
In 2025, 5-year survival is 95-100% for stage III. Therapies reduce recurrence to 20%. By 2030, immunotherapy could make curable.
Sources
The information for locally advanced prostate cancer is sourced from Cleveland Clinic’s “Prostate Cancer: Symptoms, Causes & Treatment” for causes; Mayo Clinic’s “Prostate cancer – Symptoms and causes” for symptoms; Prostate Cancer UK’s “Locally advanced prostate cancer” for overview; Macmillan’s “Locally advanced prostate cancer | Macmillan Cancer Support” for support; Urology Care Foundation’s “Prostate Cancer – Early-Stage – Symptoms” for stages; NCI’s “Prostate Cancer Treatment” for treatment; NCBI’s “Prostate Cancer – StatPearls” for exam; Johns Hopkins’s “Prostate Cancer Prognosis” for prognosis; Mayo Clinic’s “Prostate cancer – Diagnosis and treatment” for diagnosis; OncoDaily’s “Prostate Cancer Cure Rate: What Patients Should Know in 2025” for 2025 cure rates.