Glioma
Glioma: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.
Disclaimer:
This blog is for informational purposes only and should not be taken as medical advice. Content is sourced from third parties, and we do not guarantee accuracy or accept any liability for its use. Always consult a qualified healthcare professional for medical guidance.
What is Glioma?
Glioma is a primary brain tumor from glial cells, including astrocytoma, oligodendroglioma, ependymoma, with grades I-IV (glioblastoma, grade IV, most aggressive, 50% of gliomas). In 2025, ~24,000 US cases, affecting all ages but peaking in 60s.
Symptoms
Symptoms include headaches (morning, worsening), seizures, nausea, vomiting, cognitive changes (memory, personality), weakness, speech/vision issues, balance problems. Depend on location/size. In 2025, symptoms prompt MRI.
Causes
Causes include genetic mutations (IDH1/2 in low-grade, EGFR in high-grade), radiation exposure, hereditary syndromes (Li-Fraumeni). No strong lifestyle links. In 2025, microenvironment/immune factors are key.
Diagnosis
Diagnosis uses MRI/CT for mass, biopsy for grade/molecular markers (IDH, 1p/19q), EEG for seizures. In 2025, AI and NGS classify subtypes accurately.
Treatment
Low-grade: surgery + observation/radiation. High-grade: surgery, radiation, temozolomide, TTFields. Targeted (IDH inhibitors), immunotherapy. In 2025, CAR-T slows growth.
Future Outlook
In 2025, 5-year survival is 60% low-grade, 5% glioblastoma. Dual CAR-T extends glioblastoma survival. By 2030, vaccines/AI could raise to 20% for high-grade.
Sources
The information for glioma is sourced from Cleveland Clinic’s “Glioma: What It Is, Causes, Symptoms, Treatment & Prognosis” for prognosis; Brain Tumour Research’s “Glioma | High and Low Grade | Brain Tumour Types” for types; Mayo Clinic’s “Glioma – Symptoms and causes” for causes; OncoDaily’s “Glioblastoma: Causes, Symptoms, Diagnosis, Treatment, and Latest Research” for research; NCBI’s “Gliomas – StatPearls” for outcomes; Pacific Neuroscience Institute’s “Glioma & Glioblastoma Symptoms, Diagnosis and Treatment” for treatment; NORD’s “Glioma – Symptoms, Causes, Treatment” for symptoms; ASTRO’s “ASTRO updates guideline on radiation therapy for high-grade glioma” for guidelines; ScienceDirect’s “Gliomas in adults: Guidance on investigations, diagnosis, treatment” for management; GBM Research’s “What Is Glioblastoma and How To Identify | Causes and Symptoms” for identification.