Fallopian Tube Cancer
Fallopian Tube Cancer: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.: Symptoms, Causes, Diagnosis, Treatment, and Future Outlook.
Disclaimer:
This blog is for informational purposes only and should not be taken as medical advice. Content is sourced from third parties, and we do not guarantee accuracy or accept any liability for its use. Always consult a qualified healthcare professional for medical guidance.
What is Fallopian Tube Cancer?
Fallopian tube cancer is a rare gynecologic malignancy arising in the fallopian tubes, often high-grade serous carcinoma (HGSC, 90%), similar to ovarian/peritoneal cancers. It’s localised early but spreads quickly to peritoneum/ovaries. In 2025, it’s grouped with ovarian (20,890 US cases), median age 60-65, rare (1% of gynecologic cancers).
Symptoms
Symptoms include abdominal/pelvic pain, bloating, vaginal discharge (watery/bloody), irregular bleeding, and mass sensation. Advanced causes ascites, bowel changes, fatigue. Often mimics ovarian cancer. In 2025, symptoms prompt imaging.
Causes
Causes include BRCA1/2 mutations (20-30%, high risk), family history, nulliparity, endometriosis, and chronic inflammation. STIC (serous tubal intraepithelial carcinoma) is precursor. In 2025, salpingectomy reduces risk in high-risk women.
Diagnosis
Diagnosis uses transvaginal ultrasound, CA-125 blood test (elevated in 80%), CT/MRI for staging, and laparoscopy/biopsy. Molecular testing for BRCA. In 2025, liquid biopsies aid detection.
Treatment
Surgery (salpingo-oophorectomy, hysterectomy, lymphadenectomy) is primary, with staging. Chemotherapy (carboplatin + paclitaxel) for advanced. PARP inhibitors (olaparib) for BRCA+. In 2025, immunotherapy combinations improve responses.
Future Outlook
In 2025, 5-year survival is 50-60% for localised, 20-30% for advanced. PARP and targeted therapies extend survival to 4-5 years in BRCA+. By 2030, preventive salpingectomy and vaccines could reduce incidence by 50%.
Sources
The information for fallopian tube cancer is sourced from PMC’s “Cancer of the ovary, fallopian tube, and peritoneum: 2025 update” for 2025 updates; Cleveland Clinic’s “Fallopian Tube Cancer: Symptoms, Diagnosis & Treatment” for symptoms; Cancer Center’s “Fallopian Tube Cancer Symptoms, Treatment & Survival Rate” for treatment; NCI’s “Ovarian Epithelial, Fallopian, & Peritoneal Cancer Treatment” for treatment; Mayo Clinic’s “Ovarian cancer – Diagnosis and treatment” for diagnosis; OncoDaily’s “Ovarian Cancer Cure Rate: What Patients Should Know in 2025” for prognosis; MD Anderson’s “What is Fallopian Tube Cancer? Symptoms, Risk Factors & Treatments” for risks; Cancer Australia’s “Fallopian Tube cancer” for overview; ACS’s “Ovarian Cancer Survival Rates” for survival; Not These Ovaries’ “Understanding Ovarian Cancer: Symptoms, Risk Factors, and Early Detection” for detection.